2023

Guo HC*, Yu X, Liu Y, Paik DT, David T Paik, Justesen JM, Chandy MJ, Jahng JW, Zhang TJ, Wu WJ, Rwere F, Pokhrel S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC. SGLT2i ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant. Science Translational Medicine. 2023 Jan 25;15(680):eabp9952.  doi: 10.1126/scitranslmed.abp9952. PMID: 36696485.

2022

❖ Wang YJ, Zhang XC, Lam CK, Guo HC, Wang C, Zhang S, Wu JC, Snyder M, Li JJ. Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome. Cell Systems. 2022;13, 1–16. PMID: 36167075.

2021

Guo HC*, Liu LC, Nishiga M, Wu JC. Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs. Trends in Genetics. 2021; 37, 1109-1123. PMID: 34509299; PMCID: PMC8578372.

2020

❖ Wilson KD*, Ameen M*, Guo HC* (co-first), Abilez OJ, Tian L, Mumbach MR, Diecke S, Qin X, Liu Y, Yang H, Ma N, Gaddam S, Cunningham NJ, Gu M, Neofytou E, Prado M, Hildebrandt TB, Karakikes I, Chang HY, Wu JC. Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates. Dev Cell. 2020 July 28: S1534-5807(20)30580-3. PMID: 32763147; PMCID: PMC7529962.

❖ Ho Harvey, Guo HC, Means S, Tang J and Hunter P. Maternal smoking induced cardiovascular risks in fetuses: how can in silico models help? Front Bioeng Biotechnol. 2020; 8: 97. PMID: 32140462; PMCID: 7042462.

2019

❖ Guo HC*, Tian L*, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC. Single-cell RNA-sequencing of human embryonic stem cell differentiation delineates effects of nicotine on embryonic development. Stem Cell Reports. 2019; 12(4):772-786. 

PMID: 30827876. PMCID: 6449785.

❖ Belbachir N*, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo HC, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. Eur Heart J. 2019; 40(37):3081-3094. PMID: 31114854; PMCID: 6769825. 

❖ Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo HC, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling cardiovascular risks of e-cigarettes with human-induced pluripotent stem cell-derived endothelial cells. J Am Coll Cardiol. 2019; 73(21):2722-2737. PMID: 31146818; PMCID: 6637948. 

❖ Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo HC, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. A human iPSC double-reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles. Cell Stem Cell. 2019; 24(5):802-811.e5. PMID: 30880024; PMCID: 6499654. 

2018

❖ Lee J, Shao NY, Paik DT, Wu H, Guo HC, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 drives cardiac lineage commitment through stage-specific transcriptional activation. Cell Stem Cell. 2018; 22(3):428-444.e5 PMID: 29499155; PMCID: 5929163. 

❖ Zhang JZ, Guo HC, Wu JC. Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology. Curr Opin Biotechnol. 2018: 66-73. doi: 10.1016/j.copbio.2018.03.002. PMID: 29579626; PMCID: 6082724. 

❖ Nishiga M, Guo HC, Wu JC. Induced pluripotent stem cells as a biopharmaceutical factory for extracellular vesicles. Eur Heart J. 2018; 39(20):1848-1850. PMID: 29547885; PMCID: 5963295. 

2016

❖ Toh CX, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S, Ma D, Goh GY, Khattar E, Yang L, Tergaonkar V, Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H, Lim YP, Bard FA, Loh YH. RNAi reveals phase-specific clonal regulators of human somatic cell reprogramming. Cell Rep. 2016; 15(12):2597-607. PMID: 27292646. 

❖ Zhang W*, Ni P*, Mou C*, Zhang Y*, Guo HC* (co-first), Zhao T, Loh YH, Chen L. Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Sci Rep. 2016; 6:26804. PMID: 27226076; PMCID: 4881025. 

2015

❖ Yang BX*, El Farran CA*, Guo HC * (co-first), Yu T*, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Bard FA, Loh YH. Systematic identification of factors for provirus silencing in embryonic stem cells. Cell. 2015; 163(1):230-45. PMID: 26365490; PMCID: 4686136. 

❖ Chen H, Guo R, Zhang Q, Guo HC, Yang M, Wu Z, Gao S, Liu L, Chen L. Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2015; 112(44):E5936-43. PMID: 26483458; PMCID: 4640739. 

2012

❖ Wu Z, Yang M, Liu H, Guo HC, Wang Y, Cheng H, Chen L. Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem. 2012; 287(45):38295-304. PMID: 22977234; PMCID: 3488098. 

Link to my Bibliography: 

https://www.ncbi.nlm.nih.gov/myncbi/1viGoe-GylYkC/bibliography/public/